Dear Colleague, We are delighted to announce the publication of Volume 7, Number 1 of the Journal of Huntington’s Disease (JHD). | In this issue, the second instalment of the Huntington's Disease (HD) Clinical Trials Corner is published. This section was introduced into the journal last year, and we are gratified that the inaugural article was the most viewed JHD article during the October 2017 period, and was one of the top ten most-viewed articles of 2017. We interpret this as evidence of a desire in our community for well-curated and comprehensive information about clinical trials in HD. Drs Wild and Rodrigues have done a wonderful job preparing this new JHD feature and have succeeded in presenting this very complex information in an accessible format. The Clinical Trials Corner will be a recurring, open access feature in JHD. The current issue's article includes a summary table listing the trials discussed in detail in the previous edition, and which will be updated in each successive Corner. We trust that our readers will continue to find this exciting new feature of JHD useful and informative. | This issue also contains one open acess review article. The full contents of this issue can be accessed from the list below. | Kind regards, Editors-in-Chief Blair R. Leavitt, MD, CM The University of British Columbia Vancouver, BC, Canada b.leavitt@iospress.com Leslie M. Thompson, PhD University of California, Irvine Irvine, CA, USA l.thompson@iospress.com | Click on links below to view more: Review Article Pridopidine: Overview of Pharmacology and Rationale for its Use in Huntington’s Disease – Open Access Waters, Susanna | Tedroff, Joakim | Ponten, Henrik | Klamer, Daniel | Sonesson, Clas | Waters, Nicholas Research Articles HttQ111/+ Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction Kovalenko, Marina | Milnerwood, Austen | Giordano, James | St. Claire, Jason | Guide, Jolene R. | Stromberg, Mary | Gillis, Tammy | Sapp, Ellen | DiFiglia, Marian | MacDonald, Marcy E. | Carroll, Jeffrey B. | Lee, Jong-Min | Tappan, Susan | Raymond, Lynn | Wheeler, Vanessa C. Inhibition of TRPC1-Dependent Store-Operated Calcium Entry Improves Synaptic Stability and Motor Performance in a Mouse Model of Huntington’s Disease Wu, Jun | Ryskamp, Daniel | Birnbaumer, Lutz | Bezprozvanny, Ilya A Genetic Study of Psychosis in Huntington’s Disease: Evidence for the Involvement of Glutamate Signaling Pathways Tsuang, Debby W. | Greenwood, Tiffany A. | Jayadev, Suman | Davis, Marie | Shutes-David, Andrew | Bird, Thomas D. Early Neurodegeneration in R6/2 Mice Carrying the Huntington’s Disease Mutation with a Super-Expanded CAG Repeat, Despite Normal Lifespan Kielar, Catherine | Jennifer Morton, A. Age at Death and Causes of Death in Patients with Huntington Disease in Norway in 1986–2015 Solberg, Olga Karin | Filkuková, Petra | Frich, Jan C. | Feragen, Kristin J. Billaud Huntington's Disease Clinical Trials Corner: February 2018 – Open Access Rodrigues, Filipe B. | Wild, Edward J. Upcoming Meetings Related to Huntington’s Disease – Openly Available | Most Read JHD Articles in January 2018 Cerebrospinal Fluid Biomarkers for Huntington’s Disease – Open Access (Review Article in Vol.5, Iss.1, 2016) Byrne, Lauren M. | Wild, Edward J. Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington’s Disease – Open Access (Review Article in Vol.6, Iss.4, 2017) Simmons, Danielle A. Clinical Trials Corner: September 2017 – Open Access (Article in Vol.6, Iss.3, 2017) Rodrigues, Filipe B. | Wild, Edward J. Aquatherapy for Neurodegenerative Disorders – Open Access (Review Article in Vol.3, Iss.1, 2014) Plecash, Alyson R. | Leavitt, Blair R. Physical Therapy and Exercise Interventions in Huntington’s Disease: A Mixed Methods Systematic Review – Open Access (Research Article in Vol.6, Iss.3, 2017) Fritz, Nora E. | Rao, Ashwini K. | Kegelmeyer, Deb | Kloos, Anne | Busse, Monica | Hartel, Lynda | Carrier, Judith | Quinn, Lori | Indexed in: PubMed/MEDLINE Scopus | As a member of our research community, we would like to invite you to contribute your own articles to the Journal of Huntington's Disease. JHD offers contributing authors many benefits, including rigorous peer review, speedy manuscript processing, online pre-publication and an Open Access option. Submit Your Manuscript Electronically View Detailed Instructions to Authors Follow us on Facebook for news related to JHD and Huntington’s disease research with insightful commentary by JHD Media Editor Dr. Joan Steffan. Join the discussion! | |