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Gait Disorders Special Issue of JAD

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Gait Disorders in Alzheimer's Disease and Other Dementias

All articles openly available online during #WorldAlzMonth & to mid-November

We are pleased to announce a new special issue of the Journal of Alzheimer's Disease (JAD) (Volume 71, Supplement 1) is available now. The content of this issue, which is openly available online throughout World Alzheimer's Month and beyond, is focused on gait disorders. Although the main clinical hallmark of dementia is cognitive impairment and decline, motor impairments, such as gait disorders, have been commonly described, mostly in late stages. However, studies have shown that gait disorders, particularly slowing gait, may be present at early stages of dementia or may even predict who will be at risk of progressing to dementia.

"This special issue presents the current state of knowledge on the role of gait disturbances and quantitative gait analyses to be used as a motor biomarker to define subtypes of cognitive profiles and to predict cognitive decline and dementias," comment the guest editors. "Similarly, this issue contributes to the understanding of mechanisms underlying the gait and cognition interaction, and reviews the management of cognitive and motor decline using assistive devices and physical activity and exercise training in Alzheimer's disease."

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Manuel Montero-Odasso

Manuel Montero-Odasso, MD, PhD, is a senior editor of JAD, Professor of Medicine and Epidemiology and Biostatistics at University of Western Ontario and Director of the Gait and Brain Lab at Parkwood Institute in London, ON, Canada. His research focus is in the relation between mobility and cognitive problems in older adults. This includes a cohort study aimed to test gait disturbances as early predictor of dementia and mobility decline in people with early cognitive problem no dementia. His research goal is to understand the mechanisms and potential treatment of age-related mobility and cognitive decline.


George Perry

George Perry, PhD, is editor-in-chief of JAD, Chair in Neurobiology at the University of Texas at San Antonio, and Chief Scientist at the Brain Health Consortium in San Antonio, TX, USA. His research focuses on oxidative stress as a mechanism underlying Alzheimer’s disease. His lab is working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. Figuring out how the brain’s cells respond to free radicals is critical to interrupting the progress of the disease and could lead to new interventions for patients as young as those in their 30s and 40s.

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JAD, Volume 71, Supplement 1 / 2019

This special issue has 14 research articles, one of which is open access. Coinciding with World Alzheimer's Month, all content in this issue will be openly available from September to mid-November. To view the entire issue, go here.

Until mid-Nov 2019, this issue is freely available to read, download and share!


Gait Disorders in Alzheimer’s Disease and Other Dementias: There is Something in the Way You Walk
Montero-Odasso, Manuel | Perry, George

Gait Characteristics and Cognitive Decline: A Longitudinal Population-Based Study
Jayakody, Oshadi | Breslin, Monique | Srikanth, Velandai | Callisaya, Michele

Associations Between Gait Speed and Cognitive Domains in Older People with Cognitive Impairment
Toots, Annika T.M. | Taylor, Morag E. | Lord, Stephen R. | Close, Jacqueline C.T.

Switching Ability Mediates the Age-Related Difference in Timed Up and Go Performance
Langeard, Antoine | Houdeib, Ramzi | Saillant, Kathia | Kaushal, Navin | Lussier, Maxime | Bherer, Louis

Are Cognitive Subtypes Associated with Dual-Task Gait Performance in a Clinical Setting?
Cullen, Stephanie | Borrie, Michael | Carroll, Susan | Sarquis-Adamson, Yanina | Pieruccini-Faria, Frederico | McKay, Scott | Montero-Odasso, Manuel

Dual-Task Performance and Neurodegeneration: Correlations Between Timed Up-and-Go Dual-Task Test Outcomes and Alzheimer’s Disease Cerebrospinal Fluid BiomarkersOpen Access
Åhman, Hanna Bozkurt | Giedraitis, Vilmantas | Cedervall, Ylva | Lennhed, Björn | Berglund, Lars | McKee, Kevin | Kilander, Lena | Rosendahl, Erik | Ingelsson, Martin | Åberg, Anna Cristina

Frailty and Risk of Incident Motoric Cognitive Risk Syndrome
Sathyan, Sanish | Ayers, Emmeline | Gao, Tina | Milman, Sofiya | Barzilai, Nir | Rockwood, Kenneth | Verghese, Joe

Gait Dysfunction in Motoric Cognitive Risk Syndrome
Ayers, Emmeline | Verghese, Joe

Older People with Dementia Have Reduced Daily-Life Activity and Impaired Daily-Life Gait When Compared to Age-Sex Matched Controls
Taylor, Morag E. | Brodie, Matthew A. | van Schooten, Kimberley S. | Delbaere, Kim | Close, Jacqueline C.T. | Payne, Narelle | Webster, Lyndell | Chow, Jessica | McInerney, Garth | Kurrle, Susan E. | Lord, Stephen R.

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September 2019

Every year in September across the globe, efforts are made to increase awareness of AD and dementia – and the ongoing research into the disease – during World Alzheimer's Month (#WorldAlzMonth). JAD, publishing more research papers per year on AD than any other journal, is advancing knowledge in the field. It continues to push for a diversity of approaches to AD, and its Editor-in-Chief George Perry is the key driver in this. He comments: "As well as therapeutic targets that fall well within the bounds of the amyloid hypothesis, some researchers are calling for an exploration of ideas that are beyond the mainstream.”

To mark World Alzheimer's Day on September 21 this year, we are opening up the content of our latest issue, making it freely available online until the end of the month. We are calling on the JAD community to spread awareness of JAD content during the rest of this month also.

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Help Spread the News of this Special Issue!

In the spirit of spreading awareness of Alzheimer's disease and the amazing research that is ongoing during #WorldAlzMonth, please share news of this JAD Gait Special Issue by forwarding this mailing on to friends and colleagues. Simply hit the "Forward" link at the foot of this message, or share / post / tweet / email this short link to your contacts:


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