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Volume 75, Issue 4 / 2020 Online

Dementia in the COVID-19 PeriodOpen Access
Korczyn, Amos D.

Photobiomodulation for Alzheimer’s Disease: Translating Basic Research to Clinical Application
Enengl, Joachim | Hamblin, Michael R. | Dungel, Peter

Brain Aging, Cardiovascular Diseases, Mixed Dementia, and Frailty in the Oldest Old: From Brain Phenotype to Clinical Expression
Rosa, Gianmarco | Giannotti, Chiara | Martella, Lucia | Massa, Federico | Serafini, Gianluca | Pardini, Matteo | Nobili, Flavio Mariano | Monacelli, Fiammetta | et al.

Evolution of the Research Literature and the Scientific Community of Alzheimer’s Disease from 1983-2017: A 35-Year Survey
Robert, Claude | Wilson, Concepción S. | Lipton, Richard B. | Arreto, Charles-Daniel

Fear of Dementia in the General Population: Findings from the German Socio-Economic Panel (GSOEP)
Hajek, André | König, Hans-Helmut

Gamma Entrainment in a Large Retrospective Cohort: Implications for Photic Stimulation Therapy for Alzheimer’s Disease
Zibrandtsen, Ivan C. | Agger, Mikkel | Kjaer, Troels W.

Brief Cognitive Tests Used in Primary Care Cannot Accurately Differentiate Mild Cognitive Impairment from Subjective Cognitive DeclineOpen Access
Petrazzuoli, Ferdinando | Vestberg, Susanna | Midlöv, Patrik | Thulesius, Hans | Stomrud, Erik | Palmqvist, Sebastian

Alzheimer’s Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active GingipainsOpen Access
Haditsch, Ursula | Roth, Theresa | Rodriguez, Leo | Hancock, Sandy | Cecere, Thomas | Nguyen, Mai | Arastu-Kapur, Shirin | Broce, Sean | Raha, Debasish | et al.

Effect of Mentally Challenging Occupations on Incident Dementia Differs Between African Americans and Non-Hispanic Whites
Hyun, Jinshil | Hall, Charles B. | Sliwinski, Martin J. | Katz, Mindy J. | Wang, Cuiling | Ezzati, Ali | Lipton, Richard B.

Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study
Amariglio, Rebecca E. | Buckley, Rachel F. | Rabin, Jennifer S. | Papp, Kathryn V. | Quiroz, Yakeel T. | Mormino, Elizabeth C. | Sparks, Kathryn P.

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Volume 75, Issue 3 / 2020 Online

Amyloid Metabolism and Amyloid-Targeting Blood-Based Biomarkers of Alzheimer’s Disease
Pyun, Jung-Min | Kang, Min Ju | Ryoo, Nayoung | Suh, Jeewon | Youn, Young Chul | Park, Young Ho | Kim, SangYun

Incidence of Young Onset Dementia in Central Norway: A Population-Based StudyOpen Access
Kvello-Alme, Marte | Bråthen, Geir | White, Linda R. | Sando, Sigrid Botne

Combining Select Blood-Based Biomarkers with Neuropsychological Assessment to Detect Mild Cognitive Impairment among Mexican Americans
Petersen, Melissa | Hall, James | Parsons, Thomas | Johnson, Leigh | O’Bryant, Sid

Cerebrospinal Fluid and MRI Biomarkers in Neurodegenerative Diseases: A Retrospective Memory Clinic-Based StudyOpen Access
Kaipainen, Aku | Jääskeläinen, Olli | Liu, Yawu | Haapalinna, Fanni | Nykänen, Niko | Vanninen, Ritva | Koivisto, Anne M. | Julkunen, Valtteri | Remes, Anne M. | Herukka, Sanna-Kaisa

Effect of Wii Fit Exercise on Balance of Older Adults with Neurocognitive Disorders: A Meta-Analysis
Sultana, Munira | Bryant, Dianne | Orange, J.B. | Beedie, Taylor | Montero-Odasso, Manuel

Odor Identification Impairment and Change with Cholinesterase Inhibitor Treatment in Mild Cognitive Impairment
Devanand, D.P. | Liu, Xinhua | Chunga, Richard E. | Cohen, Hannah | Andrews, Howard | Schofield, Peter W. | Stern, Yaakov | Huey, Edward D. | Choi, Jongwoo | Pelton, Gregory H.

Quantifying and Describing the Natural History and Costs of Alzheimer’s Disease and Effects of Hypothetical InterventionsOpen Access
Wimo, Anders | Handels, Ron | Winblad, Bengt | Black, Christopher M. | Johansson, Gunilla | Salomonsson, Stina | Eriksdotter, Maria | Khandker, Rezaul K.

Effects of LDL Cholesterol and Statin Use on Verbal Learning and Memory in Older Adults at Genetic Risk for Alzheimer’s Disease
Wroolie, Tonita | Roat-Shumway, Siena | Watson, Katie | Reiman, Eric | Rasgon, Natalie

Flickering Red-Light Stimulus for Promoting Coherent 40 Hz Neural Oscillation: A Feasibility Study
Sahin, Levent | Figueiro, Mariana G.

Novel Markers of Angiogenesis in the Setting of Cognitive Impairment and Dementia
Callahan, Christopher M. | Apostolova, Liana G. | Gao, Sujuan | Risacher, Shannon L. | Case, Jamie | Saykin, Andrew J. | Lane, Kathleen A. | Swinford, Cecily G. | Yoder, Mervin C.

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In the News

Recent press releases relating to JAD content

Study Results Offer New Hope for Treatment of Patients with Dementia

In a study published in JAD 75:2, TauRx reported that the drug it is developing for treatment of Alzheimer's disease (hydromethylthionine) also has significant pharmacological activity in behavioural variant fronto-temporal dementia. Corresponding author Claude Wischik comments: “These new results provide independent confirmation that hydromethylthionine has important pharmacological activity on brain structure and function in neurodegenerative diseases caused by abnormal protein aggregation.”

View the full press release here

Open Access Study:
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia


Three Stages to COVID-19 Brain Damage Identified

A review article to be published in the next issue of JAD (76:1) outlines COVID-19’s effect on the nervous system, classifying brain damage caused by COVID-19 into three stages. One of the authors, Majid Fotuhi, MD, PhD, encourages the adoption of this three-stage classification, calls for more research on COVID-19's long-term effects on the brain, and stresses the need for patients to receive a brain MRI before leaving the hospital. “We are learning that a significant number of hospitalized COVID-19 patients have various degrees of brain impairment. As a medical community, we need to monitor these patients over time as some of them may develop cognitive decline, attention deficit, brain fog, or Alzheimer’s disease in the future. There is a lot we can do to promote brain healing in COVID-19 patients, but first we must understand the nature and severity of their neurological deficits," explains Dr. Fotuhi.

View the full press release here

Open Access Study:
Neurobiology of COVID-19

Watch out for more COVID-19 content coming in JAD 76:1; view all such IOS Press content here.

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Most Viewed JAD Articles in May 2020

Listing the popular papers via the IOS Press Content Library published recently (in Vols.74 & 75)

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal DementiaOpen Access (Research Article in Vol.75, Iss.2, 2020; View Press Release)
Shiells, Helen | Schelter, Bjoern O. | Bentham, Peter | Baddeley, Thomas C. | Rubino, Christopher M. | Ganesan, Harish | Hammel, Jeffrey | Vuksanovic, Vesna | et al.

Is Alzheimer’s Disease a Liver Disease of the Brain?Open Access (Review Article in Vol.75, Iss.1, 2020)
Bassendine, Margaret F. | Taylor-Robinson, Simon D. | Fertleman, Michael | Khan, Michael | Neely, Dermot

Use of Immersive Virtual Reality in the Assessment and Treatment of Alzheimer’s Disease: A Systematic ReviewOpen Access (Research Article in Vol.75, Iss.1, 2020)
Clay, Felix | Howett, David | FitzGerald, James | Fletcher, Paul | Chan, Dennis | Price, Annabel

Costs of Early Stage Alzheimer’s Disease in the United States: Cross-Sectional Analysis of a Prospective Cohort Study (GERAS-US)Open Access (Research Article in Vol.75, Iss.2, 2020)
Robinson, Rebecca L. | Rentz, Dorene M. | Andrews, Jeffrey Scott | Zagar, Anthony | Kim, Yongin | Bruemmer, Valerie | Schwartz, Ronald L. | Ye, Wenyu | Fillit, Howard M.

From Polygenic Scores to Precision Medicine in Alzheimer’s Disease: A Systematic ReviewOpen Access (Research Article in Vol.74, Iss.4, 2020)
Harrison, Judith R. | Mistry, Sumit | Muskett, Natalie | Escott-Price, Valentina

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