Review Articles Altered Neural Networks in the Papez Circuit: Implications for Cognitive Dysfunction after Cerebral Ischemia – Open Access Escobar, Iris | Xu, Jing | Jackson, Charles W. | Perez-Pinzon, Miguel A. Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges – Open Access Castellani, Rudy J. | Perry, George Contributions by the Brain Renin-Angiotensin System to Memory, Cognition, and Alzheimer’s Disease Wright, John W. | Harding, Joseph W. Other Content Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer’s Disease and Correlates with Cognitive Impairment Oeckl, Patrick | Halbgebauer, Steffen | Anderl-Straub, Sarah | Steinacker, Petra | Huss, André M. | Neugebauer, Hermann | von Arnim, Christine A.F. | Diehl-Schmid, Janine | Grimmer, Timo | Kornhuber, Johannes | Lewczuk, Piotr | Danek, Adrian | Consortium for Frontotemporal Lobar Degeneration German | Ludolph, Albert C. | Otto, Markus Cognitive Effects of White Matter Pathology in Normal and Pathological Aging – Open Access Kaskikallio, Alar | Karrasch, Mira | Rinne, Juha O. | Tuokkola, Terhi | Parkkola, Riitta | Grönholm-Nyman, Petra Identifying Unmet Needs of Family Dementia Caregivers: Results of the Baseline Assessment of a Cluster-Randomized Controlled Intervention Trial – Open Access Zwingmann, Ina | Michalowsky, Bernhard | Esser, Alexander | Kaczynski, Anika | Monsees, Jessica | Keller, Armin | Hertel, Johannes | Wucherer, Diana | Thyrian, Jochen René | Eichler, Tilly | Kilimann, Ingo | Teipel, Stefan | Dreier Wolfgramm, Adina | Hoffmann, Wolfgang A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Assessing Safety, Tolerability, and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer’s Disease – Open Access Farlow, Martin R. | Thompson, Richard E. | Wei, Lee-Jen | Tuchman, Alan J. | Grenier, Elaine | Crockford, David | Wilke, Susanne | Benison, Jeffrey | Alkon, Daniel L. Dietary Patterns and Cognitive Health in Older Adults: A Systematic Review Chen, Xi | Maguire, Brook | Brodaty, Henry | O’Leary, Fiona Improved Differential Diagnosis of Alzheimer’s Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers – Open Access Khoonsari, Payam Emami | Shevchenko, Ganna | Herman, Stephanie | Remnestål, Julia | Giedraitis, Vilmantas | Brundin, RoseMarie | Degerman Gunnarsson, Malin | Kilander, Lena | Zetterberg, Henrik | Nilsson, Peter | Lannfelt, Lars | Ingelsson, Martin | Kultima, Kim Two Year Outcomes, Cognitive and Behavioral Markers of Decline in Healthy, Cognitively Normal Older Persons with Global Deterioration Scale Stage 2 (Subjective Cognitive Decline with Impairment) Reisberg, Barry | Torossian, Carol | Shulman, Melanie B. | Monteiro, Isabel | Boksay, Istvan | Golomb, James | Guillo Benarous, Francoise | Ulysse, Anaztasia | Oo, Thet | Vedvyas, Alok | Rao, Julia A. | Marsh, Karyn | Kluger, Alan | Sangha, Jaspreet | Hassan, Mudasar | Alshalabi, Munther | Arain, Fauzia | et al. Association between Adipokines and Biomarkers of Alzheimer’s Disease: A Cross-Sectional Study Letra, Liliana | Matafome, Paulo | Rodrigues, Tiago | Duro, Diana | Lemos, Raquel | Baldeiras, Inês | Patrício, Miguel | Castelo-Branco, Miguel | Caetano, Gina | Seiça, Raquel | Santana, Isabel Evaluation of Medicare Claims Data as a Tool to Identify Dementia Lee, Eunjung | Gatz, Margaret | Tseng, Chiuchen | Schneider, Lon S. | Pawluczyk, Sonia | Wu, Anna H. | Deapen, Dennis | Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging – Open Access Krell-Roesch, Janina | Feder, Nathanael T. | Roberts, Rosebud O. | Mielke, Michelle M. | Christianson, Teresa J. | Knopman, David S. | Petersen, Ronald C. | Geda, Yonas E. Olfactory Function is Associated with Cognitive Performance: Results of the Heinz Nixdorf Recall Study Tebrügge, Sarah | Winkler, Angela | Gerards, Diana | Weimar, Christian | Moebus, Susanne | Jöckel, Karl-Heinz | Erbel, Raimund | Jokisch, Martha | on behalf of the Heinz Nixdorf Recall Study Investigative Group Polypharmacy and Potentially Inappropriate Medication in People with Dementia: A Nationwide Study Kristensen, Rachel Underlien | Nørgaard, Ane | Jensen-Dahm, Christina | Gasse, Christiane | Wimberley, Theresa | Waldemar, Gunhild Exposure to General Anesthesia and Risk of Dementia: A Nationwide Population-Based Cohort Study Kim, Clara Tammy | Myung, Woojae | Lewis, Matthew | Lee, Hyewon | Kim, Satbyul Estella | Lee, Kyungsang | Lee, Chunsoo | Choi, Junbae | Kim, Ho | Carroll, Bernard J. | Kim, Doh Kwan Gait in Mild Alzheimer’s Disease: Feasibility of Multi-Center Measurement in the Clinic and Home with Body-Worn Sensors: A Pilot Study Mc Ardle, Ríona | Morris, Rosie | Hickey, Aodhán | Del Din, Silvia | Koychev, Ivan | Gunn, Roger N. | Lawson, Jennifer | Zamboni, Giovanna | Ridha, Basil | Sahakian, Barbara J. | Rowe, James B. | Thomas, Alan | Zetterberg, Henrik | MacKay, Clare | Lovestone, Simon | Rochesteron, Lynn | on behalf of the Deep and Frequent Phenotyping study team | Results from a Danish Population-Based Study | JAD's most read article this month relates to a Danish study that appeared in JAD Vol.67, Iss.1, 2019. To discover more about this research, read the recent news item. The open access study "Vital Exhaustion and Incidence of Dementia: Results from the Copenhagen City Heart Study" by Islamoska, et al. concludes that psychological distress is a risk factor for dementia. Lead author Sabrina Islamoska from the Department of Public Health, University of Copenhagen, has shown a dose-response relation between symptoms of vital exhaustion reported in late midlife and the risk of dementia later in life. "Vital exhaustion" is a mental state of psychological distress. The results of this study support that distress in late midlife may potentially increase the risk of dementia in later life. Despite adjusting for several other well-known risk factors for dementia, such as sex, marital status, lower educational level, lifestyle factors and comorbidities, the risk of dementia associated with vital exhaustion did not change. “Stress can have severe and harmful consequences not just for our brain health, but our health in general. Cardiovascular risk factors are well-known modifiable risk factors for dementia, and in some countries, a stagnation or even a decreasing incidence of dementia has been observed. Our study indicates that we can go further in the prevention of dementia by addressing psychological risk factors for dementia,” Islamoska said. Read the full article here. | Most Read JAD Articles in January 2019 Listing articles published only in 2018 and 2019 so you can read the most popular recent content Vital Exhaustion and Incidence of Dementia: Results from the Copenhagen City Heart Study – Open Access (Research Article in Vol.67, Isss1, 2019) Islamoska, Sabrina | Ishtiak-Ahmed, Kazi | Hansen, Åse Marie | Grynderup, Matias Brødsgaard | Mortensen, Erik Lykke | Garde, Anne Helene | Gyntelberg, Finn | Prescott, Eva Irene Bossano | Török, Eszter | Waldemar, Gunhild | Nabe-Nielsen, Kirsten Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges – Open Access (Review Article in Vol.67, Iss.2, 2019) Castellani, Rudy J. | Perry, George The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade – Open Access (Review Article in Vol.64, Iss.s1, 2018) Cline, Erika N. | Bicca, Maíra Assunção | Viola, Kirsten L. | Klein, William L. Challenges for Optimizing Real-World Evidence in Alzheimer’s Disease: The ROADMAP Project – Open Access (Editorial in Vol.67, Iss.2, 2019) Gallacher, John | de Reydet de Vulpillieres, Frederic | Amzal, Billy | Angehrn, Zuzanna | Bexelius, Christin | Bintener, Christophe | Bouvy, Jacoline C. | Campo, Laura | Diaz, Carlos | Georges, Jean | Gray, Alastair | Hottgenroth, Antje | et al. Improved Differential Diagnosis of Alzheimer’s Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers – Open Access (Research Article in Vol.67, Iss.2, 2019) Khoonsari, Payam Emami | Shevchenko, Ganna | Herman, Stephanie | Remnestål, Julia | Giedraitis, Vilmantas | Brundin, RoseMarie | Degerman Gunnarsson, Malin | Kilander, Lena | Zetterberg, Henrik | Nilsson, Peter | Lannfelt, Lars | Ingelsson, Martin | Kultima, Kim | Please share the JAD Newsletter with your colleagues! | If you know any colleagues and fellow researchers who are not signed up to receive the JAD newsletter, we invite you to share this mailing with them. They can sign up at: tiny.cc/JADsignup We hope news of our open access Journal of Alzheimer's Disease Reports will also be of interest? Sign up here to be sure of receiving the quarterly JADR mailing direct to your inbox! 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