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Dear Colleague,

We are delighted to announce the publication of Volume 5, Issue 4 of Bladder Cancer (BLC). The full contents are freely available online and can be browsed in full below.

In this issue, we are pleased to include a Festchrift honoring the illustrious career of Bladder Cancer board member Prof. Ellen Catharina Zwarthoff. Comments Editor-in-Chief Dan Theodorescu: "Ellen has established very clearly that genetic detection of bladder cancer based on noninvasive urinary analysis is not only possible but is clinically feasible and has significant utility."

This issue also hosts an outstanding selection of content, including one systematic review and four research articles. From the editors of the regular journal sections, there are also new Challenging Case and Clinical Trials Corner contributions. All articles can be accessed via the links below.


Call for Papers

As a member of our research community, we would like to invite you to contribute your own research articles to Bladder Cancer, which offers contributing authors many benefits:

• First class Editorial Board
• Rigorous peer review and speedy manuscript processing
• Rapid online publication (pre-press) on acceptance
• Articles are currently published Open Access with no article processing fee

Submit your manuscript online via msTracker
View detailed Instructions to Authors
Aims and Scope

We look forward to working with you.

Best wishes,


Seth P. Lerner, MD
Scott Department of Urology
Baylor College of Medicine
Houston, Texas, USA

Dan Theodorescu, MD, PhD
Samuel Oschin Comprehensive Cancer Institute
Cedars-Sinai Medical Center
Los Angeles, California, USA


All content is currently freely available to all readers


Festschrift Professor Ellen Catharina Zwarthoff
Zuiverloon, T. | Bangma, C. | Boormans, J. | de Jong, C. | de Jong, J. | van Kessel, K. | Theodorescu, D. | Knowles, M. | Hartmann, A.

Systematic Review

Modeling Tumor Heterogeneity in Bladder Cancer: The Current State of the Field and Future Needs
Amanda Seyer, B.S. | Lehman, Heather L. | DeGraff, David J.

Research Articles

Non-Coding Mutations in Urothelial Bladder Cancer: Biological and Clinical Relevance and Potential Utility as Biomarkers
Jeeta, Ruhana R. | Gordon, Naheema S. | Baxter, Laurab | Goel, Anshita | Noyvert, Boris | Ott, Sascha | Boucher, Rebecca H. | Humayun-Zakaria, Nada | Arnold, Roland | et al.

Adverse Events During Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer
Salminen, Antti P. | Montoya Perez, Ileana | Klén, Riku | Ettala, Otto O. | Syvänen, Kari T. | Elo, Laura L. | Boström, Peter J.

Cisplatin Ineligibility for Patients With Metastatic Urothelial Carcinoma: A Survey of Clinical Practice Perspectives Among US Oncologists
Galsky, Matthew D. | Ma, Esprit | Shah-Manek, Bijal | Mills, Rosalina | Ha, Long | Krebsbach, Craig | Blouin, Eric | Tayama, Darren | Ogale, Sarika

Bladder Cancer Multidisciplinary Clinic (BCMC) Model Influences Disease Assessment and Impacts Treatment Recommendations
Diamantopoulos, Leonidas N. | Winters, Brian R. | Grivas, Petros | Ngo, Steven D. | Zeng, Jing | Hsieh, Andrew C. | Gore, John L. | Liao, Jay J. | Yu, Evan Y. | Schade, George R. | et al.

Other Content

Challenging Cases in Urothelial Cancer
Soloway, Mark S.

Clinical Trials Corner
Agarwal, Piyush K. | Sternberg, Cora N.


Most Viewed BLC Articles in Q4 2019

Listing the most read content via the IOS Press content website published in 2019 BLC issues:

Clinical Development of FGFR3 Inhibitors for the Treatment of Urothelial Cancer (Review Article in Vol.5, Iss.2, 2019)
Ibrahim, Tony | Gizzi, Marco | Bahleda, Ratislav | Loriot, Yohann

Systematic Review: Targeting HER2 in Bladder Cancer (Review Article in Vol.5, Iss.1, 2019)
Koshkin, Vadim S. | O’Donnell, Peter | Yu, Evan Y. | Grivas, Petros

CIS of the Bladder: Significance and Implications for Therapy (Review Article in Vol.5, Iss.3, 2019)
Mirabal, Jorge Rivera | Taylor, John A. | Lerner, Seth P.

Investigating the STING Pathway to Explain Mechanisms for BCG Failures in Non-Muscle Invasive Bladder Cancer: Prognostic and Therapeutic Implications (Research Article in Vol.5, Iss.3, 2019)
Koti, Madhuri | Chenard, Stephen | Nersesian, Sarah | Vidotto, Thiago | Morales, Alvaro | Siemens, D. Robert

The Role of Myeloid Derived Suppressor Cells in Urothelial Carcinoma Immunotherapy (Review Article in Vol.5, Iss.2, 2019)
Puttmann, Kathleen | Duggan, Megan | Mortazavi, Amir | Diaz, Dayssy Alexandra | Carson III, William E. | Sundi, Debasish

Intravesical Therapy – BCG and Beyond (Meeting Report in Vol.5, Iss.1, 2019)
Grossman, H.B. | Lamm, D. | Sjödahl, Gottfrid | O’Donnell, Michael | Hahn, Noah | Kamat, Ashish


2020 Bladder Cancer Research Innovation Award | Apply Now

BCAN is seeking applicants for its 2020 Bladder Cancer Research Innovation Award. The award is intended to support the work of an investigator with an exceptionally novel and creative project with "great potential to produce breakthroughs in our understanding of the management of bladder cancer." One proposal will be funded for $300,000 over two years ($150,000 per year).

The aim of the 2020 Bladder Cancer Research Innovation Award is to support exceptionally novel and creative projects with great potential to produce breakthroughs in our understanding of bladder cancer. The proposed research may be basic, translational, clinical or epidemiological and must have direct applicability and relevance to bladder cancer. Innovation, either conceptual or technological, is essential.

Interested applicants must submit a Letter of Intent by: Wednesday, January 15, 2020.

Individuals who are then invited to submit full research proposals and compete for the award will have until mid-April to submit, with the award decision being announced in June 2020.

For further details, visit the BCAN website.


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