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Volume 71, Issue 2 / 2019 Available Online

REVIEW ARTICLES
Airborne Magnetite- and Iron-Rich Pollution Nanoparticles: Potential Neurotoxicants and Environmental Risk Factors for Neurodegenerative Disease, Including Alzheimer’s Disease
Maher, Barbara A.

Bilingualism and Dementia: Cognitive Reserve to Linguistic Competency
Mendez, Mario F.

PPAR α Between Aspirin and Plaque Clearance
Chandra, Sujyoti | Roy, Avik | Patel, Dhruv R. | Pahan, Kalipada

RESEARCH ARTICLES
Exercise Training in Amnestic Mild Cognitive Impairment: A One-Year Randomized Controlled Trial
Tarumi, Takashi | Rossetti, Heidi | Thomas, Binu P. | Harris, Thomas | Tseng, Benjamin Y. | Turner, Marcel | Wang, Ciwen | German, Zohre | Martin-Cook, Kristin | Stowe, Ann M. | et al.

Efficacy and Safety of Cholinesterase Inhibitors for Mild Cognitive Impairment:A Systematic Review and Meta-Analysis
Matsunaga, Shinji | Fujishiro, Hiroshige | Takechi, Hajime

Tracking Cognitive Performance in the General Population and in Patients with Mild Cognitive Impairment with a Self-Applied Computerized Test (Brain on Track)
Ruano, Luis | Severo, Milton | Sousa, Andreia | Ruano, Catarina | Branco, Mariana | Barreto, Rui | Moreira, Sandra | Araújo, Natália | Pinto, Paula | Pais, Joana | Lunet, Nuno | Cruz, Vítor Tedim

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older SubjectsOpen Access
Qiu, Ruolun | Ahn, Jae Eun | Alexander, Robert | Brodney, Michael A. | He, Ping | Leurent, Claire | Mancuso, Jessica | Margolin, Richard A. | Tankisheva, Ekaterina | Chen, Danny

Neuron-Specific Apolipoprotein E4 (1-272) Fragment Induces Tau Hyperphosphorylation and Axonopathy via Triggering Endoplasmic Reticulum Stress
Liang, Tao | Xue, Feixiao | Hang, Weijian | Wen, Bin | Zhang, Qianying | Chen, Jiehui | Liu, Xiaofeng | Chen, Juan

APOE ɛ4 Gene Dose and Sex Effects on Alzheimer’s Disease MRI Biomarkers in Older Adults with Mild Cognitive Impairment Open Access
Hobel, Zachary | Isenberg, A. Lisette | Raghupathy, Dhvani | Mack, Wendy | Pa, Judy | for the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing

A Brief Ischemic Postconditioning Protects Against Amyloid-β Peptide Neurotoxicity by Downregulating MLK3-MKK3/6-P38MAPK Signal in Rat Hippocampus
Li, Hui | Luo, Xiao-Bing | Xu, Yan | Hou, Xiao-Yu

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Volume 71, Supplement 1 / 2019 Access Now!

JAD Gait Disorders Special Issue

Last chance to view the openly available for #WorldAlzMonth!

Frailty and Risk of Incident Motoric Cognitive Risk Syndrome
Sathyan, Sanish | Ayers, Emmeline | Gao, Tina | Milman, Sofiya | Barzilai, Nir | Rockwood, Kenneth | Verghese, Joe

Effect of Learning to Use a Mobility Aid on Gait and Cognitive Demands in People with Mild to Moderate Alzheimer’s Disease: Part I – Cane
Hunter, Susan W. | Divine, Alison | Omana, Humberto | Wittich, Walter | Hill, Keith D. | Johnson, Andrew M. | Holmes, Jeffrey D.

Effect of Learning to Use a Mobility Aid on Gait and Cognitive Demands in People with Mild to Moderate Alzheimer’s Disease: Part II – 4-Wheeled WalkerOpen Access
Hunter, Susan W. | Divine, Alison | Omana, Humberto | Wittich, Walter | Hill, Keith D. | Johnson, Andrew M. | Holmes, Jeffrey D.

Older People with Dementia Have Reduced Daily-Life Activity and Impaired Daily-Life Gait When Compared to Age-Sex Matched Controls
Taylor, Morag E. | Brodie, Matthew A. | van Schooten, Kimberley S. | Delbaere, Kim | Close, Jacqueline C.T. | Payne, Narelle | Webster, Lyndell | Chow, Jessica | McInerney, Garth | et al.

This issue was made openly available for World Alzheimer's Month in September. We have now extended the time frame & the content will remain freely available until mid-October!

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In the News

Recent press releases relating to recent JAD content

Alzheimer’s Memory Loss Reversed by New Head Device Using Electromagnetic Waves

Findings from an open label clinical trial showed reversal of cognitive impairment in Alzheimer’s disease patients after just two months of treatment using the company’s wearable head device for in-home treatment. Results demonstrate that Transcranial Electromagnetic Treatment (TEMT) was safe in all eight participating patients with mild to moderate AD and enhanced cognitive performance in seven of them, as measured by their ADAS-cog score, which is the benchmark for testing AD therapeutics.

Open Access Study:
A Clinical Trial of Transcranial Electromagnetic Treatment in Alzheimer’s Disease: Cognitive Enhancement and Associated Changes in CSF, Blood and Brain Imaging

Read the full press release here

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Excercise Could Slow Withering Effects of Alzheimer's

Exercising several times a week may delay brain deterioration in people at high risk for Alzheimer’s disease, according to a study that scientists say merits further research to establish whether fitness can affect the progression of dementia. Research from UT Southwestern found that people who had accumulation of amyloid beta in the brain experienced slower degeneration in a region of the brain crucial for memory if they exercised regularly for one year.

Open Access Study:
Exercise Training in Amnestic Mild Cognitive Impairment: A One-Year Randomized Controlled Trial

Read the full press release here

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Most Read JAD Articles in September 2019

Most read content via the IOS Press content website published in 2019 JAD issues.

A Clinical Trial of Transcranial Electromagnetic Treatment in Alzheimer’s Disease: Cognitive Enhancement and Associated Changes in Cerebrospinal Fluid, Blood, and Brain ImagingOpen Access (Research Article in Vol.71, Iss.1, 2019) (View the Press Release)
Arendash, Gary | Cao, Chuanhai | Abulaban, Haitham | Baranowski, Rob | Wisniewski, Gary | Becerra, Lino | Andel, Ross | Lin, Xiaoyang | Zhang, Xiaolin | Wittwer, David | Moulton, Jay | Arrington, John | Smith, Amanda

Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future DirectionsOpen Access (Review Article in Pre-Press, 2019)
Elmaleh, David R. | Farlow, Martin R. | Conti, Peter S. | Tompkins, Ronald G. | Kundakovic, Ljiljana | Tanzi, Rudolph E.

Tip of the Iceberg: Assessing the Global Socioeconomic Costs of Alzheimer’s Disease and Related Dementias and Strategic Implications for StakeholdersOpen Access (Review Article in Vol.70, Iss.2, 2019) (View the Press Release)
El-Hayek, Youssef H. | Wiley, Ryan E. | Khoury, Charles P. | Daya, Ritesh P. | Ballard, Clive | Evans, Alison R. | Karran, Michael | Molinuevo, José Luis | Norton, Matthew | Atri, Alireza

Gait Disorders in Alzheimer’s Disease and Other Dementias: There is Something in the Way You WalkOpenly Available (Editorial in Vol.71, Iss.s1, 2019)
Montero-Odasso, Manuel | Perry, George

Treatment Combinations for Alzheimer’s Disease: Current and Future Pharmacotherapy OptionsOpen Access (Review Article in Vol.67, Iss.3, 2019)
Cummings, Jeffrey L. | Tong, Gary | Ballard, Clive

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Featured JAD CME Article

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