"What If Cannabis Cured Cancer summarizes the remarkable research findings of recent years about the cancer-protective effects of novel compounds in m

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"What If Cannabis Cured Cancer summarizes the remarkable research findings of recent years about the cancer-protective effects of novel compounds in marijuana. Most medical doctors are not aware of this information and its implications for preventio

Breast & Weed

Cannabinoids: A new hope for breast cancer therapy?

Breast cancer is a very common disease that affects approximately 1 in 10 women at some point in their lives. Importantly, breast cancer cannot be considered a single disease as it is characterized by distinct pathological and molecular subtypes that are treated with different therapies and have diverse clinical outcomes. Although some highly successful treatments have been developed, certain breast tumors are resistant to conventional therapies and a considerable number of them relapse. Therefore, new strategies are urgently needed, and the challenge for the future will most likely be the development of individualized therapies that specifically target each patient’s tumor. Experimental evidence accumulated during
the last decade supports that cannabinoids, the active components of Cannabis sativa and their derivatives, possess anticancer activity. Thus, these compounds exert anti-proliferative, pro-apoptotic, antimigratory and anti-invasive actions in a wide spectrum of cancer cells in culture. Moreover, tumor growth, angiogenesis and metastasis are hampered by cannabinoids in xenograft-based and genetically-engineered mouse models of cancer. This review summarizes our current knowledge on the antitumor potential of cannabinoids in breast cancer, which suggests that cannabinoid-based medicines may be useful for the treatment of most breast tumor subtypes.
2012 Elsevier Ltd. All rights reserved.

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What is the history behind it?

Marijuana plants were made into fiber for rope and textiles, oil was taken from its seeds, and some cultures used it in religious rituals. It was described in Indian and Chinese medical texts more than 3,000 years ago. It was used to treat conditions such as beriberi, constipation, gout, malaria, rheumatism, and absent-mindedness, as well as depression, insomnia, vomiting, tetanus, and coughs. In the middle ages, herbalists used it externally to help muscle and joint pain.

In the mid-1800s, the plant was mentioned as a treatment for gonorrhea and angina (chest pains related to heart disease). It was also used to treat intestinal pain, cholera, epilepsy, strychnine poisoning, bronchitis, whooping cough, and asthma. In the US and Europe, marijuana extracts were prepared and sold for medicinal use as sedatives and pain relievers, to help appetite and sexual problems. By the early 20th century, it was noted that the extracts varied in their effects. Their actions in the body varied based on where the marijuana came from, how it was prepared, and how old it was. Other medicines became available that were more predictable and easier to use.

Things were already changing in the US in 1937, when marijuana use (even by doctors) was taxed. Then Congress passed a law in 1951 that classified marijuana as a narcotic drug. In 1970, marijuana was defined in a new law, the Controlled Substances Act, as a Schedule 1 drug -- a drug with no accepted medical use and with the potential for abuse. While marijuana is legal in many parts of Asia and the Middle East, it remains illegal in most Western countries.

In recent decades, marijuana has been the subject of extensive medical research using more advanced methods of testing as specific active compounds have been isolated. But political and legal controversies surrounding its status as an illegal substance, as well as concerns about potentially harmful side effects, have hampered the process of scientific inquiry in many countries, including the United States.

Despite this, researchers continue to study the compounds in marijuana for possible medical applications. Two prescription drugs based on marijuana compounds have been approved in the United States, and a third has been approved in Canada and Europe. The prescription drug dronabinol is an active ingredient of marijuana. It is used for patients with chemotherapy-related nausea and vomiting that does not respond to usual treatments, as well as for people with serious weight loss due to AIDS. Nabilone is another drug based on cannabinoids that is used for nausea and vomiting after chemotherapy. Other compounds are being tested for possible use as drugs.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of Shawn's or its staff.

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