Dear Colleague, We are delighted to announce the publication of Volume 8, Issue 1 of the Journal of Huntington’s Disease (JHD). This issue contains a selection of open acess content, including two research articles, one review article, and the latest Clinical Trials Corner instalment. The full contents of this issue can be accessed from the list below. Kind regards, Editors-in-Chief Blair R. Leavitt, MD The University of British Columbia Vancouver, BC, Canada b.leavitt@iospress.com Leslie M. Thompson, PhD University of California, Irvine Irvine, CA, USA l.thompson@iospress.com | Click on links below to view more: Review Article Obsessive-Compulsive and Perseverative Behaviors in Huntington’s Disease – Open Access Oosterloo, Mayke | Craufurd, David | Nijsten, Hanneke | van Duijn, Erik Research Articles Disease-Modification in Huntington’s Disease: Moving Away from a Single-Target Approach Jensen, Melanie P. | Barker, Roger A. Activity Behaviour of Minipigs Transgenic for the Huntington Gene Rieke, Lorena | Fels, Michaela | Schubert, Robin | Habbel, Benjamin | Matheis, Tamara | Schuldenzucker, Verena | Kemper, Nicole | Reilmann, Ralf Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Pig Transgenic Model Expressing Human Mutant Huntingtin Smatlikova, Petra | Juhas, Stefan | Juhasova, Jana | Suchy, Tomas | Hubalek Kalbacova, Marie | Ellederova, Zdenka | Motlik, Jan | Klima, Jiri Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease – Open Access Tousley, Adelaide | Iuliano, Maria | Weisman, Elizabeth | Sapp, Ellen | Zhang, Ningzhe | Vodicka, Petr | Alexander, Jonathan | Aviolat, Hubert | Gatune, Leah | Reeves, Patrick | Li, Xueyi | et al. Risk Assessment for Huntington’s Disease for (Future) Offspring Requires Offering Preconceptional CAG Analysis to Both Partners Tibben, Aad | Dondorp, Wybo J. | de Wert, Guido M. | de Die-Smulders, Christine E. | Losekoot, Moniek | Bijlsma, Emilia K. Attitudes of Potential Participants Towards Molecular Therapy Trials in Huntington’s Disease – Open Access Bardakjian, Tanya M. | Naczi, Kaylee Faulkner | Gonzalez-Alegre, Pedro Cognitive Fitness to Drive in Huntington’s Disease: Assessing the Clinical Utility of DriveSafe DriveAware Farrell, Hayden J. | Andrews, Sophie C. | Ryan, Nicholas P. | Davis, Marie-Claire | Gordon, Stephanie | Stout, Julie C. | Fisher, Fiona Contemporary Dance Practice Improves Motor Function and Body Representation in Huntington’s Disease: A Pilot Study Trinkler, Iris | Chéhère, Philippe | Salgues, Julie | Monin, Marie-Lorraine | Tezenas du Montcel, Sophie | Khani, Sonia | Gargiulo, Marcela | Durr, Alexandra Assessment of Caregiver Burden in Huntington’s Disease Yu, Margaret | Tan, Kenny | Koloms, Kimberly | Bega, Danny Other Content Huntington’s Disease Clinical Trials Corner: January 2019 – Open Access Rodrigues, Filipe B. | Wild, Edward J. Upcoming Meetings Related to Huntington’s Disease – Openly Available | Most Read JHD Articles in January 2019 Listing articles published only in 2018 and 2019 so you can read the most popular recent content Clinical Management of Neuropsychiatric Symptoms of Huntington Disease: Expert-Based Consensus Guidelines on Agitation, Anxiety, Apathy, Psychosis and Sleep Disorders – Open Access (Research Article in Vol.7, Iss.4, 2018) Anderson, Karen E. | van Duijn, Erik | Craufurd, David | Drazinic, Carolyn | Edmondson, Mary | Goodman, Nathan | van Kammen, Daniel | Loy, Clement | Priller, Josef | Goodman, LaVonne Veatch Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease – Open Access (Research Article in Vol.8, Iss.1, 2019) Tousley, Adelaide | Iuliano, Maria | Weisman, Elizabeth | Sapp, Ellen | Zhang, Ningzhe | Vodicka, Petr | Alexander, Jonathan | Aviolat, Hubert | Gatune, Leah | Reeves, Patrick | Li, Xueyi | et al. Transcriptional Regulation of the Huntingtin Gene – Open Access (Review Article in Vol.7, Iss.4, 2018) Thomson, Sarah B. | Leavitt, Blair R. Disease-Modification in Huntington’s Disease: Moving Away from a Single-Target Approach (Article Commentary in Vol.8, Iss.1, 2019) Jensen, Melanie P. | Barker, Roger A. Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice – Open Access (Research Article in Vol.7, Iss.4, 2018) Morozko, Eva L. | Ochaba, Joseph | Hernandez, Sarah J. | Lau, Alice | Sanchez, Isabella | Orellana, Iliana | Kopan, Lexi | Crapser, Joshua | Duong, Janet H. | Overman, Julia | Yeung, Silvia | Steffan, Joan S. | Reidling, Jack | Thompson, Leslie M. | CHDI Therapeutics Conference JHD Drinks Reception | Tue 26 Feb The 14th Annual HD Therapeutics Conference will be begin on February 25 in Palm Springs, CA, USA. The conference program promises to cover all aspects of drug discovery related to Huntington's disease. JHD information will be available at the event, including print copies of our hot-off-the-press current issue, which will be available during the drinks reception at the end of lectures on Tuesday 26 February in the hotel lobby. All delegates are invited by JHD's Editors-in-Chief Blair R. Leavitt and Leslie M. Thompson to attend the journal's drinks reception. Please join us at the Parker Hotel Lobby to meet colleagues, share ideas, and make new connections in the pursuit of therapeutics for Huntington's disease. Follow our live coverage of the CHDI event via Twitter! | Stem cells are featured in HD research in two articles in this JHD issue: "Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells in Pig Transgenic Model Expressing Human Mutant Huntingtin" by Smatlikova, et al.; and "Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease" by Tousley, et al. With this in mind, we introduce a new journal from the publisher of JHD. StemJournal is an open access forum for innovative scientific contributions from the many fields of research on stem cells. The launch of this new peer-reviewed journal for the stem cell community has an ultimate aim: to keep pace with developments in this burgeoning field and to lower the barrier to publishing truly integrative biomedical research on stem cells. Submissions are now welcome via the journal's website: stemjnl.org. | Sign Ups & Social Media Help Spread the News of JHD! | If you know of any colleagues or fellow researchers who are not yet signed up to receive the newsletter, we invite you to share this mailing with them. Click on the sign-up link at the bottom of this email or access here. JHD also has a social media presence! why not take the time today to follow us on Twitter and find us on Facebook? Be part of the discussion! | |