Dear Colleague, We are delighted to announce the publication of Volume 8, Issue 4 of the Journal of Huntington’s Disease (JHD). This issue contains a selection of open acess content, including two review articles and three research articles. The full contents of this issue can be accessed from the list below, along with the most read JHD articles and details of two research studies published in JHD that have been making the news. Kind regards, Editors-in-Chief Blair R. Leavitt, MD The University of British Columbia Vancouver, BC, Canada b.leavitt@iospress.com Leslie M. Thompson, PhD University of California, Irvine Irvine, CA, USA l.thompson@iospress.com | REVIEW ARTICLES The Role of Hypothalamic Pathology for Non-Motor Features of Huntington’s Disease – Open Access Cheong, Rachel Y. | Gabery, Sanaz | Petersén, Åsa Therapeutic Use of Music, Dance, and Rhythmic Auditory Cueing for Patients with Huntington’s Disease: A Systematic Review – Open Access Schwartz, Anna E. | van Walsem, Marleen R. | Brean, Are | Frich, Jan C. ARTICLE COMMENTARY Raising Awareness of Therapeutic Misconception and Optimism Around Clinical Trials in Huntington’s Disease – Open Access de Bot, Susanne Tamara RESEARCH ARTICLES Positive Attitudes and Therapeutic Misconception Around Hypothetical Clinical Trial Participation in the Huntington’s Disease Community – Open Access Cotter, Kristina | Siskind, Carly E. | Sha, Sharon J. | Hanson-Kahn, Andrea K. The Prospective Huntington At-Risk Observational Study (PHAROS): The Emotional Well-Being, Safety and Feasibility of Long-Term Research Participation Kayson, Elise | Eberly, Shirley | Anderson, Karen E. | Marder, Karen | Shoulson, Ira | Oakes, David | Young, Anne B. | Biglan, Kevin | Hersch, Steven | on behalf of The Huntington Study Group PHAROS Investigators Progressive Polyglutamine Repeat Expansion in Peripheral Blood Cells and Sperm of Transgenic Huntington’s Disease Monkeys – Open Access Clever, Faye | Cho, In Ki | Yang, Jingjing | Chan, Anthony W.S. Increased Serotonin Transporter Expression in Huntington’s Disease Patients Is Not Consistently Replicated in Murine Models He, Yanqing | Suofu, Yalikun | Yablonska, Svitlana | Wang, Xiaoming | Larkin, Timothy M. | Kim, Jinho | Carlisle, Diane L. | Friedlander, Robert M. Recall and Recognition Discriminability in Parkinson’s Disease and Huntington’s Disease Van Etten, Emily J. | Graves, Lisa V. | Taylor, Brad | Holden, Heather M. | Lopez, Francesca V. | Williams, McKenna E. | Pirogovsky-Turk, Eva | Corey-Bloom, Jody | Filoteo, J. Vincent | Delis, Dean C. | Gilbert, Paul E. Validation of Neuro-QoL and PROMIS Mental Health Patient Reported Outcome Measures in Persons with Huntington Disease Carlozzi, Noelle E. | Goodnight, Siera | Kratz, Anna L. | Stout, Julie C. | McCormack, Michael K. | Paulsen, Jane S. | Boileau, Nicholas R. | Cella, David | Ready, Rebecca E. Impaired Isometric Force Matching in Upper and Lower Limbs Revealed by Quantitative Motor Assessments in Huntington’s Disease Medzech, Sabrina | Sass, Christian | Bohlen, Stefan | Lange, Herwig W. | Koch, Raphael | Schubert, Robin | Ringelstein, E. Bernd | Reilmann, Ralf Obsessive-Compulsive Symptoms are Less Common in Huntington’s Disease than Reported Earlier Hoffmann, Rainer | Schröder, Natalie | Brüne, Martin | von Hein, Sarah | Saft, Carsten Addressing the Value of Multidisciplinary Clinical Care in Huntington’s Disease: A Snapshot of a New Huntington’s Disease Center Bardakjian, Tanya M. | Klapper, Jennifer | Carey, Adrianna | Wood, Julia | Pauly, Meredith | Gasper, Kelly | Lawler, Kathy | Tran, Baochan | Bell, Yuliis | Zwil, Alex | Gonzalez-Alegre, Pedro Quality of Care for Huntington’s Disease in the United States: Findings from a National Survey of Patients and Caregivers Anderson, Karen E. | Griffin, Jack | Kinel, Al | Shaikh, Abdul R. | Olofintuyi, Temitope | Ramirez, Stevan | Steinman, Joni | Yohrling, George J. | Kinel, Shari | on behalf of the Huntington Study Group OTHER CONTENT Upcoming Meetings Related to Huntington’s Disease – Openly Available | Most Read JHD Articles in October 2019 Listing articles published only in 2018 and 2019 so you can read the most popular recent content Therapeutic Use of Music, Dance, and Rhythmic Auditory Cueing for Patients with Huntington’s Disease: A Systematic Review – Open Access (Review Article in Vol.8, Iss.4, 2019) Schwartz, Anna E. | van Walsem, Marleen R. | Brean, Are | Frich, Jan C. Characterization of Neurodevelopmental Abnormalities in iPSC-Derived Striatal Cultures from Patients with Huntington’s Disease – Open Access (Research Article in Vol.8, Iss.3, 2019) TMathkar, Pranav P. | Suresh, Divya | Dunn, James | Tom, Colton M. | Mattis, Virginia B. Huntington’s Disease Clinical Trials Corner: June 2019 – Openly Available (Clinical Trials Corner in Vol.8, Iss.3, 2019) Rodrigues, Filipe B. | Ferreira, Joaquim J. | Wild, Edward J. The Role of Hypothalamic Pathology for Non-Motor Features of Huntington’s Disease – Open Access (Review Article in Vol.8, Iss.4, 2019) Cheong, Rachel Y. | Gabery, Sanaz | Petersén, Åsa Clinical Management of Neuropsychiatric Symptoms of Huntington Disease: Expert-Based Consensus Guidelines on Agitation, Anxiety, Apathy, Psychosis and Sleep Disorders – Open Access (Research Article in Vol.7, Iss.4, 2018) Anderson, Karen E. | van Duijn, Erik | Craufurd, David | Drazinic, Carolyn | Edmondson, Mary | Goodman, Nathan | van Kammen, Daniel | Loy, Clement | Priller, Josef | Goodman, LaVonne V. | In the News Recent press releases relating to recent JHD content | Q-Suite Motor Assessment Tool Promising for Evaluating Huntington’s Disease Therapies in Children In clinical trials of adults with Huntington's disease the Q-Suite Motor Assessment Tool has proven to be helpful to detect and quantitate subtle motor abnormalities. With the anticipated arrival of preventive gene therapies that will most likely be administered to young children known to be carriers of the HD mutation, it is crucial to have a means to evaluate motor abilities in children that is sensitive to the child's stage of development. Promising results of a feasibility study published in JND indicate that Q-Motor can address this need. Link to Study: A Feasibility Study of Quantitative Motor Assessments in Children Using the Q-Motor Suite Read the full press release here | Sign Ups & Social Media Help Spread the News of JHD! | If you know of any colleagues or fellow researchers who are not yet signed up to receive the newsletter, we invite you to share this mailing with them. Click on the sign-up link at the bottom of this email or access here. JHD also has a social media presence! why not take the time today to follow us on Twitter and find us on Facebook? 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