Dear Colleague, We are delighted to announce the publication of Volume 8, Issue 3 of the Journal of Huntington’s Disease (JHD). This issue contains a selection of open acess content, including one review article, one research article, and the latest Clinical Trials Corner instalment. The full contents of this issue can be accessed from the list below, along with the most read JHD articles, and an item about increasing Huntington's disease (HD) awareness courtesy of our own social media editor Lauren Byrne. Kind regards, Editors-in-Chief Blair R. Leavitt, MD The University of British Columbia Vancouver, BC, Canada b.leavitt@iospress.com Leslie M. Thompson, PhD University of California, Irvine Irvine, CA, USA l.thompson@iospress.com | REVIEW ARTICLE Glycation in Huntington’s Disease: A Possible Modifier and Target for Intervention – Open Access Brás, Inês Caldeira | König, Annekatrin | Outeiro, Tiago Fleming RESEARCH ARTICLES Characterization of Neurodevelopmental Abnormalities in iPSC-Derived Striatal Cultures from Patients with Huntington’s Disease – Open Access Mathkar, Pranav P. | Suresh, Divya | Dunn, James | Tom, Colton M. | Mattis, Virginia B. Differential Levels and Phosphorylation of Type 1 Inositol 1,4,5-Trisphosphate Receptor in Four Different Murine Models of Huntington Disease Post, Joakim Iver | Leergaard, Trygve B. | Ratz, Veronika | Walaas, S. Ivar | von Hörsten, Stephan | Nissen-Meyer, Lise Sofie H. Electroconvulsive Therapy (ECT) for Refractory Psychiatric Symptoms in Huntington’s Disease: A Case Series and Review of the Literature Adrissi, Jennifer | Nadkarni, Neil A. | Gausche, Eric | Bega, Danny Ancillary Service Utilization and Impact in Huntington’s Disease Yomtoob, Jacob | Yeh, Chen | Bega, Danny Biological Motion Perception in Huntington’s Disease Matheis, Tamara | Evinger, Craig | Schubert, Robin | Mazzola, Steven | Fels, Michaela | Kemper, Nicole | Reilmann, Ralf | Muratori, Lisa Predicting the Risk of Huntington’s Disease with Multiple Longitudinal Biomarkers Li, Fan | Li, Kan | Li, Cai | Luo, Sheng | PREDICT-HD and ENROLL-HD Investigators of the Huntington Study Group A Feasibility Study of Quantitative Motor Assessments in Children Using the Q-Motor Suite van der Plas, Ellen | Schubert, Robin | Reilmann, Ralf | Nopoulos, Peggy C. Impact of Huntington’s Disease on Mental Rotation Performance in Motor Pre-Symptomatic Individuals Nasr, Shahin | Rosas, Herminia D. OTHER CONTENT Letter in Response to Tibben et al., Risk Assessment for Huntington’s Disease for (Future) Offspring Requires Offering Preconceptional CAG Analysis to Both Partners – Openly Available Quarrell, Oliver W. | Delatycki, Martin B. | Clarke, Angus J. | Lahiri, Nayana | Craufurd, David | Miedzybrodzka, Zosia | MacLeod, Rhona | Renwick, Pamela | Tomlinson, Charlotte Reply to Oliver W Quarrell et al.: “Letter in response to Tibben et al., Risk Assessment for Huntington’s Disease for (Future) Offspring Requires Offering Preconceptional CAG Analysis to Both Partners” – Openly Available Tibben, Aad | Dondorp, Wybo J. | de Wert, Guido M. | de Die-Smulders, Christine E. | Losekoot, Moniek | Bijlsma, Emilia K. Huntington’s Disease Clinical Trials Corner: June 2019 – Open Access Rodrigues, Filipe B. | Ferreira, Joaquim J. | Wild, Edward J. Upcoming Meetings Related to Huntington’s Disease – Openly Available | Most Read JHD Articles in August 2019 Listing articles published only in 2018 and 2019 so you can read the most popular recent content Huntington’s Disease Clinical Trials Corner: January 2019 – Openly Available (Clinical Trials Corner in Vol.8, Iss.1, 2019) Rodrigues, Filipe B. | Quinn, Lori | Wild, Edward J. Characterization of Neurodevelopmental Abnormalities in iPSC-Derived Striatal Cultures from Patients with Huntington’s Disease – Open Access (Research Article in Vol.8, Iss.3, 2019) TMathkar, Pranav P. | Suresh, Divya | Dunn, James | Tom, Colton M. | Mattis, Virginia B. Clinical Management of Neuropsychiatric Symptoms of Huntington Disease: Expert-Based Consensus Guidelines on Agitation, Anxiety, Apathy, Psychosis and Sleep Disorders – Open Access (Research Article in Vol.7, Iss.4, 2018) Anderson, Karen E. | van Duijn, Erik | Craufurd, David | Drazinic, Carolyn | Edmondson, Mary | Goodman, Nathan | van Kammen, Daniel | Loy, Clement | Priller, Josef | Goodman, LaVonne Veatch Therapeutic Use of Music, Dance, and Rhythmic Auditory Cueing for Patients with Huntington’s Disease: A Systematic Review – Open Access (Research Article in pre-press, 2019) Schwartz, Anna E. | van Walsem, Marleen R. | Brean, Are | Frich, Jan C. Huntington’s Disease Clinical Trials Corner: June 2019 – Openly Available (Clinical Trials Corner in Vol.8, Iss.3, 2019) Rodrigues, Filipe B. | Ferreira, Joaquim J. | Wild, Edward J. | Spreading Huntington's Disease Awareness Let's Talk About Huntington's | #LetsTalkAboutHD | Lauren Byrne is the JHD social media editor and she is doing a great job running our Facebook and Twitter accounts. Lauren is a research associate in the Huntington's Disease Research Group, UCL Institute of Neurology, in London, UK, and she is an advocate for getting out there and spreading Huntington's disease awareness among various audiences. And that is what Lauren did recently when she appeared as a guest on "Futureproof" – a podcast by Jonathan McCrae on the Irish radio station Newstalk. A recent edition of the station's flagship science program focused on HD and the search for new and better ways to tackle the symptoms and causes despite the challenges. Lauren was on hand to give a personal interview on the topic and the full discussion can be heard via the Newstalk website (see below). This is just one of the projects that Lauren has been involved with to promote HD awareness and there are other campaigns happening in the coming months. Follow JHD on Twitter and use hashtags, such as #HDawareness and #LetsTalkAboutHD, to be kept informed. Listen to the interview by clicking below: | Sign Ups & Social Media Help Spread the News of JHD! | If you know of any colleagues or fellow researchers who are not yet signed up to receive the newsletter, we invite you to share this mailing with them. Click on the sign-up link at the bottom of this email or access here. JHD also has a social media presence! why not take the time today to follow us on Twitter and find us on Facebook? Be part of the discussion! | You are receiving this mailing as you are signed up to receive news from JHD. 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